The Giants were two wins away from playing in the Super Bowl last season, but they are lucky to have one victory through five games this season.
The G-Men face a tall task as they travel to face Buffalo on Sunday night as heavy road underdogs with plenty of offensive weapons sidelined due to injury.
Big Blue will rely on Tyrod Taylor to lead the charge as he replaces starting quarterback Daniel Jones, who is dealing with a neck injury.
Running back Saquon Barkley is questionable to return from an ankle injury, though tight end Darren Waller should play despite dealing with a groin injury.
The Giants face their second straight AFC East opponent, having lost to the Dolphins last Sunday, 31-16, as 13-point underdogs.
The Giants managed only one touchdown, a 102-yard interception return before halftime.
The Bills return home after falling to the Jaguars in London, 25-20 as 5.5-point favorites.
Buffalo trailed the entire game, while getting held to 29 rushing yards, even though quarterback Josh Allen threw for 359 yards and two touchdowns.
From a first-half perspective, the Bills have led by 10 points four times, including in each of their two home games.
Buffalo has not been a favorite of more than 7.5 points, however, in any of their first five games this season.
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The Giants have trailed by double-digits at the half in four games before losing by seven through two quarters at Miami.
This first-half line is extremely high. Maybe Taylor will give the Giants an early boost, and Buffalo could have issues in its first game back from London.
The play: Giants First Half +8.5.